Introduction

Increasingly, associations are being made between the ubiquitin system and many human diseases including cancer, neurodegeneration, metabolic disorders and viral infections. Proteolysis mediated by the ubiquitin-proteasome system is regulated by different enzymes, which recently became an attractive target for drug discoveries. LifeSensors offers a number of inhibitors enabling researchers to decipher the function of Ub/Ubl isopeptidases and conjugating enzymes. Along with classical inhibitors of Ub/Ubl isopeptidases such as Ub-vinyl methyl ester and –aldehyde, LifeSensors has a number of small molecule inhibitors. Our new addition includes inhibitors of Ub/Ubl conjugating enzymes. With an evergrowing interest in proteasomal activity that has been linked to cancer, inflammatory and autoimmune diseases, we now offer a collection of proteasome inhibitors. Several inhibitors including bortezomib are already used in the treatment of multiple myeloma. The most commonly used laboratory inhibitors, lactacystin and MG132 are now available in different quantities. 

UPP - Inhibitor Library

 
SI9032
QTY.

Ubiquitin and Ubiquitin-like VME Derivatives

 
SI440
QTY.
SI540
QTY.
SI640
QTY.
SI240
QTY.
SI340
QTY.

Ubiquitin and Ubiquitin-like Aldehyde Derivatives

 
SI450
QTY.
SI550
QTY.
SI750
QTY.
SI650
QTY.
SI250
QTY.

Proteasome Inhibitors

 
SI9730
QTY.
SI9669
QTY.
SI9790
QTY.
SI9740
QTY.
SI9780
QTY.
SI9760
QTY.
SI9710
QTY.
SI9725
QTY.
SI9715
QTY.
SI9735
QTY.
SI9720
QTY.

DUB Inhibitors

 
SI9649
QTY.
SI9669
QTY.
SI9629
QTY.
SI9639
QTY.
SI9634
QTY.
SI9689
QTY.
SI9699
QTY.
SI9619
QTY.
SI9644
QTY.
SI9679
QTY.
SI9659
QTY.

Conjugating Enzyme Inhibitors

 
SI9890
QTY.
SI9815
QTY.
SI9830
QTY.
SI9825
QTY.
SI9850
QTY.
SI9870
QTY.
SI9885
QTY.
SI9855
QTY.
SI9810
QTY.
SI9835
QTY.
SI9845
QTY.
SI9860
QTY.
SI9880
QTY.
SI9840
QTY.
SI9865
QTY.
SI9820
QTY.

P97 Inhibitors

 
SI9750
QTY.
SI9770
QTY.
SI9752
QTY.
 

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