Introduction

PROTEASOME RESEARCH TOOLS

The proteasome is a 60 subunit, highly conserved protease complex, representing the products of ~35 genes. It is composed of a 20S core and one or two 19S regulatory particles (26S). Most cellular proteins are marked for degradation by attachment of an ubiquitin chain, which leads to their rapid degradation by the 26S proteasome. The ubiquitin tag binds to the ‘lid’, a 19S particle, followed by disassembly of ubiquitin chains, protein unfolding and subsequent translocation into the central cavity of the 20S proteasome. The 19S proteasome contains 19 different proteins that have the ability to bind, deubiquitylate and unfold polyubiquitylated proteins. Unfolded proteins are further cleaved into short (3-15 amino acids) peptides. 

 

20S Proteasome

 
PS020
QTY.

26S Proteasome

 
PS026
QTY.

COP9 (CSN) Complex

 
CP009
QTY.

RPN1 and RPN2 (26S Proteasome Regulatory Subunit) Proteins

 
PS110
QTY.
PS120
QTY.

SUC-LEU-LEU-VAL-TYR-AMC (SUC-LLVY-AMC)

 

RPN11 Isopeptidase Substrates

 
SI238
QTY.
SI233
QTY.

Proteasome Inhibitors

 
SI9730
QTY.
SI9669
QTY.
SI9790
QTY.
SI9740
QTY.
SI9780
QTY.
SI9760
QTY.
SI9710
QTY.
SI9725
QTY.
SI9715
QTY.
SI9735
QTY.
SI9720
QTY.
 

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