Introduction

LifeSensors offers the largest collection of deubiquitinating (or deubiquitylating) enzyme (DUB) and Ubl deubiquitylase. These enzymes are capable of recognizing and cleaving the isopeptide bond between ubiquitin (or Ubl) moieties or between ubiquitin (or Ubl) and the target protein. Five classes of DUBs exist based on sequence homology. These families include the ubiquitin C-terminal hydrolases (UCH), the ubiquitin-specific processing proteases (USPs), the Machado-Joseph Disease domain proteases, the Otubain proteases (Otu), and JAMM domain proteases. LifeSensors DUBs and Ubl deubiquitylase can be utilized for HTS, determining Ub/Ubl specificity or Ub chain linkage type, as well as target substrate specificity.

 

per_min_UbiRho

USP Family of DUBs

 
DB505
QTY.
DB513
QTY.
DB520
QTY.
DB509
QTY.
DB525
QTY.
DB501
QTY.
DB530
QTY.
DB508
QTY.
DB506
QTY.
DB511
QTY.
DB510
QTY.
DB516
QTY.
DB507
QTY.
DB502
QTY.
DB504
QTY.
DB503
QTY.

UCH Family of DUBs

 
DB103
QTY.
DB104
QTY.
DB101
QTY.
DB102
QTY.

OTU Family of DUBs

 
DB209
QTY.
DB208
QTY.
DB201
QTY.
DB203
QTY.
DB205
QTY.
DB207
QTY.
DB206
QTY.
DB202
QTY.

JAMM Family of DUBs

 
DB301
QTY.
DB302
QTY.

MJD Family of DUBs

 
DB401
QTY.
DB402
QTY.
DB403
QTY.
DB404
QTY.

Viral-Bacterial DUBs

 
DB603
QTY.
DB602
QTY.
DB601
QTY.

Deneddylases

 
DB801
QTY.

Desumoylases

 
DB701
QTY.
DB703
QTY.
 

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