LifeSensors offers the largest collection of deubiquitinating (or deubiquitylating) enzyme (DUB) and Ubl deubiquitylase. These enzymes are capable of recognizing and cleaving the isopeptide bond between ubiquitin (or Ubl) moieties or between ubiquitin (or Ubl) and the target protein. Five classes of DUBs exist based on sequence homology. These families include the ubiquitin C-terminal hydrolases (UCH), the ubiquitin-specific processing proteases (USPs), the Machado-Joseph Disease domain proteases, the Otubain proteases (Otu), and JAMM domain proteases. LifeSensors DUBs and Ubl deubiquitylase can be utilized for HTS, determining Ub/Ubl specificity or Ub chain linkage type, as well as target substrate specificity.
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