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E3 Substrate ID, E3 Ligase Substrate Profiling Service | Catalog #: MA102
The identification of novel substrates for E3 enzymes is most efficiently achieved through the use of protein microarray technology. E3 Substrate ID™ employs a high-content microarray and LifeSensors' ubiquitin pathway expertise to identify candidate substrates for any ubiquitin E3 ligase. The service includes the following steps:
The service can be performed with one of several commercially available arrays or a custom array. LifeSensors can advise on the selection of the most appropriate array for the experiment. Screens have been performed successfully with protein arrays containing approximately 20,000 human proteins.
Array: Client-selected human protein microarray
Client material required: E3 of interest provided by client or selected from our catalog (roughly 150 µL of a 100 nM solution)
Deliverable: Raw data & statistical analysis, gene ontology (GO) clustering of potential substrates, follow-up support and lead prioritization
Turnaround: 4-6 weeks
Contact our scientists for a free consultation. Find out how LifeSensors' Ubiquitin Protein Microarray Services can provide answers to your ubiquitome-related questions.
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