A recent high-profile report in nature structural & molecular biology describes novel redox-regulatory roles for K63 ubiquitylated proteins. Using LifeSensors’ anti-K63 TUBES in combination with SILAC based proteomics, the researchers identify over 100 new K63-ubiquitylated protein targets. Furthermore, they demonstrate that K63 polyubiquitylation is important for polysome stability, protein expression and stress resistance in response to oxidative stress.
LifeSensors is at the forefront of developing new and innovative technologies that will lead to many more breakthroughs. Our pan and linkage specific TUBEs will uncover more novel roles of K48, K63, and Linear (M1) ubiquitylation.
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