PROTACs & Molecular Glues
PROTACs® (PRoteolysis-TArgeting Chimeric molecules) artificially hijack the components of the UPS to degrade a target protein. PROTAC drugs are hetero-bifunctional small molecules that contain two functional ligands connected via a linker; one ligand binds to a target protein and the other ligand binds to an E3 ligase.
E3 Ubiquitin Ligases Profiling & Screening
At LifeSensors, we have developed reagents and assays encompassing both traditional and non-traditional approaches for E3 ligase screening and profiling. LifeSensors’ small molecule library contains a collection of ligase-centric compounds, which can be employed as a gold standard for your ligase drug discovery efforts.
Mass Spectrometry Proteomics
Traditional methods for mass spectrometry-based proteomics, such as SILAC (stable isotope labeling with amino acids in cell culture), are insensitive, poorly reproducible, costly, and time consuming. LifeSensors’ TUBEs bind to all polyubiquitin chains with 1-10 nM affinity, overcoming major problems common to mass spectrometry proteomics.
SUMO-Tag Protein Expression & Purification
Protein expression and production of recombinant proteins routinely encounters problems, including formation of inclusion bodies, incorrect protein conformation, toxicity to the host cell, and low protein yield.
DUB Assays, Screening & Profiling
Deubiquitylases (DUBs) are enzymes that can reverse the effect of E3 ligases by removing the ubiquitin from the target proteins. Unlike most E3 ligases, DUBs have inherent catalytic activity that is easily targeted by small molecules.
Tools for PROTAC, Molecular Glues, and the Ubiquitin Proteasome System:
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An out of the box solution for inhibiting the ubiquitin proteasome system designed for a range of LifeSensors cellular studies.....
A Far-red color with absorbance at 650nm and emission at 665nm fused to K48 TUBE. Since the fluorophore is fused....
A Far-red color with absorbance at 650nm and emission at 665nm fused to K63 TUBE. Since the fluorophore is fused....
A Far-red color with absorbance at 650nm and emission at 665nm fused to TUBE1. Since the fluorophore is fused to....
An out of the box solution for inhibiting the ubiquitin proteasome system designed for a range of LifeSensors cellular studies.....
A Far-red color with absorbance at 650nm and emission at 665nm fused to K48 TUBE. Since the fluorophore is fused....
A Far-red color with absorbance at 650nm and emission at 665nm fused to K63 TUBE. Since the fluorophore is fused....
A Far-red color with absorbance at 650nm and emission at 665nm fused to TUBE1. Since the fluorophore is fused to....
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Understanding an E3 ligase is an essential step for choosing a target for screening in...
With ubiquitin’s core functions in plants and animals being so similar it has long been...
The functional consequences of protein polyubiquitination are determined by the type of ubiquitin chain assembled...
While direct K-RAS inhibitors represent a major therapeutic advance, targeting this oncoprotein remains a significant...
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