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Ubiquitin/Ubl Pathway Inhibitors

Increasingly, associations are being made between the ubiquitin system and many human diseases including cancer, neurodegeneration, metabolic disorders and viral infections. Proteolysis mediated by the ubiquitin-proteasome system is regulated by different enzymes, which recently became an attractive target for drug discoveries. LifeSensors offers a number of inhibitors enabling researchers to decipher the function of Ub/Ubl isopeptidases and conjugating enzymes. Along with classical inhibitors of Ub/Ubl isopeptidases such as Ub-vinyl methyl ester and –aldehyde, LifeSensors has a number of small molecule inhibitors. Our new addition includes inhibitors of Ub/Ubl conjugating enzymes. With an evergrowing interest in proteasomal activity that has been linked to cancer, inflammatory and autoimmune diseases, we now offer a collection of proteasome inhibitors. Several inhibitors including bortezomib are already used in the treatment of multiple myeloma. The most commonly used laboratory inhibitors, lactacystin and MG132 are now available in different quantities.
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HEADLINES

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LifeSensors Awarded U.S. Patent for Novel Ubiquitin Pathway Enzyme Substrates
LifeSensors, Inc., a biotech company developing cutting-edge technologies for studying the ubiquitin pathway, has been awarded a U.S. patent for the development of novel, fluorescent di- and poly-ubiquitin deubiquitinase (DUB) substrates (US 8,518,660).
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LifeSensors

LifeSensors is a proud sponsor of the 5th Annual Ubiquitin Drug Discovery & Diagnostics Conference
This year's conference will be held at the Four Seasons Hotel in Philadelphia, July 22-24 and will once again highlight the latest research taking place in the ubiquitin field. We are excited to learn about all of the latest discoveries and technical advances and hope to see you there!
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LifeSensors

LifeSensors presented an overview of ubiquitin proteomics at the 3rd GTC Conference, Ubiquitin Research and Drug Discovery, Las Vegas, February 25-26th, 2013.
Complexity of ubiquitin pathways leads to frequent questions related to identification of ubiquitin pathway enzymes (E3s and DUBs) and their substrates. An overview of biochemical proteomics for drug discovery applications including Ubiquitin Protein Microarray Services from LifeSensors was presented by Christian Loch, Assistant Director, R&D. Visit our website to find additional information about our Ubiquitin Protein Microarrays.
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UBIQUITIN RESEARCH TOOLS

EXPRESSION SYSTEMS
Ubiquitin Affinity Reagents (TUBEs)
Ubiquitin Derivatives and Chains
Conjugation Assays
Conjugating Enzymes
Isopeptidases - Assays
Isopeptidases - Enzymes
Isopeptidases - Substrates
Ubiquitin/Ubl Pathway Inhibitors
Ubiquitin/Ubl Pathway Antibodies
Ubiquitin ELISA
Ubiquitin Protein Microarray Services
SilenciX Ubiquitin Pathway Knockdown Cell Lines
Custom Ubiquitinated Peptides
Coming soon!
Proteasome Research Tools
SUMO Research Tools
     
LifeSensors

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