UBIQUITIN RESEARCH TOOLS
CHOP2 Reporter System
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Deubiquitylating enzymes (DUBs) DUBs are a class of isopeptidases that cleave ubiquitin from target proteins, including other ubiquitins. Other classes of isopeptidases perform the same function for ubiquitin-like proteins fused to their target proteins. Both conjugation and deconjugation of ubiquitin or ubiquitin-like proteins (UBLs) contribute to the maintenance of cellular homeostasis, the disruption of which can lead to disease. Accordingly, DUBs and UBL isopeptidases have been found to be overexpressed or dysregulated in a number of pathophysiologies [Nicholson et al, 2007]. Inhibition (or, in some cases, activation) of DUBs represents a novel, underexploited form of therapeutic intervention, and efforts are underway to discover or design inhibitors and activators of these enzymes that can be developed as medicines [Berlin, Tenarife meeting abstracts, 2008, Keystone meeting, 2009]. Exploring ubiquitylation with LifeSensors The importance of post-translational modification of proteins by ubiquitin and ubiquitin-like (Ubl) proteins for the control of cellular functions is becoming increasingly apparent. Novel and superior tools are needed to facilitate this research and support the growth of this rapidly expanding field of study. LifeSensors is committed to providing these tools. We have the largest collection of active deubiquitylases, Ub-ligases, and anti-DUB antibodies available commercially as well as other Ubl-conjugation/deconjugation enzymes. We are proud to announce the introduction of new reagents for dissecting the activity of these enzymes, both traditional substrates and inhibitors and our highly sensitive CHOP-reporter system. These reagents will help you uncover exciting new facets of biological process modulated through Ub/Ubl modification. |
