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SUMOpro Fusion Protein Technology.
The use of SUMOpro as a fusion system can dramatically enhance overall protein production through the enhanced protein translation, solubility, and stability. Each SUMO-fusion system requires specific proteases for removal of the fusion partner: for SUMO use SUMO Protease 1, for SUMOstar use SUMOstar Protease, and for SUMOpro-3 use SUMO Protease 2. SUMO proteases are highly specific and robust enzymes that recognize and bind to the tertiary structure of SUMO in order to correctly identify the C-terminal cleavage site on the enzymes active site. With the exception of proline, these proteases will cleave your fusion protein precisely between the C-terminus of SUMO and the N-terminus of the target protein. By recognizing the tertiary structure of the SUMO tag, this system virtually eliminates the ragged ends and non-specific cleavage seen with other proteases.