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Date: June 28, 2010
LifeSensors Launches DiUbiquitin Substrate
For Immediate Release
LifeSensors Launches DiUbiquitin Substrate
A Novel Fluorescent Assay for Ubiquitin Isopeptide Bond Cleavage
MALVERN, PA -- June 29, 2010 --LifeSensors, Inc., a biotechnology company, announces the launch of its novel physiologically relevant diubiquitin substrates for measuring isopeptide bond cleavage after filing for patent applications. This breakthrough technology, for both basic research and drug discovery targeting the ubiquitin proteasome pathway, offers sensitive, rapid, and robust fluorescent readouts of isopeptidase or de-ubquitylase (DUB) activity.
Currently, methods for measuring DUB activity utilize ubiquitin conjugates fused to a small fluorophore (e.g. rhodamine or AMC); however the non-physiological nature of these substrates has hindered drug discovery efforts in this area. Due to their chemical properties, these technologies cannot mimic a true ubiquitin isopeptidase bond.
Protein modification by the ubiquitin-proteasome system is a central mechanism involved in the regulation of critical cellular functions. De-ubiquitylases (DUBs) play a role in this regulation by cleaving the isopeptide linkage that joins the ubiquitin(s) to its target substrate. LifeSensors is proud to announce the launch of a novel internally quenched fluorescence (IQF) assay for measuring DUB activity employing diubiquitin conjugates (DiUbiquitin) as a more physiologically relevant substrate due to its true isopeptide bond. These DiUbiquitins represent a new class of substrates for measuring cleavage of isopeptide bonds in a homogeneous and continuous assay platform.
Pricing and Availability
DiUbiquitin panels from LifeSensors feature an array of different diubiquitin molecules that are linked via isopeptide bond, at either K48 or K63, the best characterized forms of poly-ubiquitin linkages. There are currently six versions of both the K48 and K63 substrates available. Trial panels for substrate evaluation including control enzyme are also available at discounted pricing. Please visit http://www.lifesensors.com/product-family-desc.php?id=67 to learn more about all substrates available to monitor DUB enzymatic activity.
LifeSensors, Inc. is the leading producer of innovative research tools for the ubiquitin and ubiquitin-like protein pathways. Its prokaryotic and eukaryotic protein expression platforms SUMOpro and SUMOstar are used worldwide to overcome bottlenecks in protein production. LifeSensors’ novel technologies enable research once not possible using a wide variety of high quality tools including enzymes, substrates and inhibitors.
For more information, visit http://www.lifesensors.com.
Contact:
Marc Scholtyssek, Director of Sales and Marketing
610-644-8845 x305
Scholtyssek@lifesensors.com
LifeSensors, Inc.
271 Great Valley Parkway,
www.lifesensors.com
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