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LifeSensors

Date: September 15, 2009
LifeSensors, Inc. Signs Distribution Agreement with Nacalai USA, Inc.
LifeSensors, Inc. Signs Distribution Agreement with Nacalai USA, Inc.
LifeSensors, Inc. manufactures Ubiquitin Proteasome Pathway (UPP) research tools and novel recombinant protein expression technologies

MALVERN, Pa. & SAN DIEGO--(BUSINESS WIRE)--Nacalai USA, Inc. has entered into a distribution agreement with LifeSensors, Inc., a Malvern, Pennsylvania, based biotechnology company for distribution of LifeSensors’ Ubiquitin Proteasome Pathway (UPP) research tools and novel recombinant protein expression technologies in Japan, Singapore, South Korea and Taiwan. Domestically, products are available directly from LifeSensors, Inc.

The agreement was executed in August of 2009 and will allow researchers in Japan, South Korea, Taiwan, and Singapore access to the innovative reagents necessary to facilitate and improve their research and drug discovery efforts.

Products

Ubiquitin Research Tools: Novel technologies such as the CHOP reporter and soon to be introduced Ubiquitin Ligase Kits will allow researchers to demonstrate novel isopeptidase activity, determine substrate specificity of a Ub/Ubl isopeptidase, and measure activity of difficult enzymes such as the Cop9 signalosome.

Expression Technologies: LifeSensors has patented the use of SUMO (Small Ubiquitin-like Modifier) as a fusion tag for recombinant protein expression in eukaryotic and prokaryotic systems. Benefits of this system include improved solubility and dramatically increased yield of the protein of interest. In addition, the tag is efficiently and cost effectively removed with no residual residues or “ragged” ends often associated with competing technologies.

About LifeSensors, Inc.

LifeSensors, Inc. is the leading producer of tools that facilitate the study the Ubiquitin Proteasome Pathway (UPP) and also develops novel technologies that use SUMO to overcome bottlenecks in protein production. LifeSensors’ novel technologies enable research once not possible, and its traditional tools (associated enzymes, substrates, inhibitors) are the highest quality available.

About Nacalai USA and Nacalai Tesque

Nacalai USA, Inc. is the wholly-owned subsidiary of Nacalai Tesque, Inc., Kyoto Japan, founded in 2005 in San Diego, California to bridge between the United States and Japan in the scientific research community. Nacalai USA strives to bring the most innovative and stringently quality-controlled biochemicals and research tools from Japan into the United States market, and also to introduce United States technologies and products into the Japanese and other Asian research markets.

Contacts:

LifeSensors, Inc., Malvern, PA
Marc Scholtyssek
Sales and Marketing Manager
610-644-8845
Scholtyssek@lifesensors.com
or
Nacalai USA, Inc., San Diego, CA
Jing Xu
Corporate Development
jxu@nacalaiusa.com
LifeSensors
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LifeSensors Launches DiUbiquitin Substrate
A Novel Fluorescent Assay for Ubiquitin Isopeptide Bond Cleavage
MALVERN, PA -- June 29, 2010 --LifeSensors, Inc., a biotechnology company, announces the launch of its novel physiologically relevant diubiquitin substrates for measuring isopeptide bond cleavage (patent applied for). This breakthrough technology, for both basic research and drug discovery targeting the ubiquitin proteasome pathway, offers sensitive, rapid, and robust fluorescent readouts of isopeptidase or de-ubquitylase (DUB) activity.
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LifeSensors

LifeSensors' Gender Sorting Technology Discussed
Feb 9th 2010 | From The Economist online
Dr Butt’s new device is an oestrogen sniffer. It relies on the fact that female embryos produce this hormone in quantity and male ones do not. The sensor uses a fine needle to penetrate both the shell and the allantoic sac of an egg. This sac is a fluid-filled membrane that cushions the embryo and helps it trade carbon dioxide for oxygen from the air. (It is also the membrane that can make peeling a hard-boiled egg such a frustrating affair.)
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LifeSensors

LifeSensors Publishes in Journal of Animal Science
2010 Jan 15.
An estrogen sensor for poultry gender sorting.

Tran HT, Ferrell W, Butt TR.

The need for segregation of poultry based on sex is driven by gender-related differences in growth rate, market age, management practices, and nutritional requirements. Each day, global poultry industry staff would ideally like to determine the gender of >150 million newly hatched birds. Currently, this can be done only manually at the hatchery, which is a virtually impossible undertaking. LifeSensors has developed a facile, rapid, and low cost yeast-based assay that distinguishes male from female embryonated eggs before hatching based on the estrogen level of their allantoic fluid.
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