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LifeSensors

Specialists in ubiquitin and related proteins.

LifeSensors is the leading producer of innovative tools that facilitate the study of the Ubiquitin Proteasome Pathway (UPP). We also develop novel technologies that utilize SUMO-fusion tags to improve yield and reduce costs of protein expression.

Product Highlights

• Check out our new K63-linkage specific TUBEs that display selectivity for polyubiquitin linked through lysine 63 over lysine 48 and lysine 11 linkages. FLAG K63-TUBE 1 is an optimized reagent for isolation and purification of K63-linked polyubiquitin from cell & tissue lysates and Biotin K63-TUBE 1 is suitable for far Western blotting, affinity purification from lysates & biological fluids, and in situ detection of K63-linked polyubiquitin.

• NEW additions to our Ub/Ubl Pathway Inhibitors: Proteasome, Conjugating Enzyme, P97, and DUB Inhibitors are now available under Ubiquitin Research Tools. These tools are for research purposes only.

• LifeSensors is pleased to announce UbiQuant™, the first sandwich ELISA kit that captures total ubiquitin (mono- and poly-ubiquitylated conjugates) in biological samples.

• LifeSensors has developed the best anti-ubiquitin antibody (VU-1) for multiple applications. This antibody reacts with mono- and polyubiquitylated proteins in Western blot analysis and is an excellent reagent for the identification of ubiquitylated proteins in cells and tissue sections (IHC/IF).

Papers of the Month

• Kirk Hamilton (Univ. of Otago, New Zealand) reviews novel technologies, including GST-TUBEs, PR-619 & DUB-Chip, for probing the ubiquitination and deubiquitination of cellular proteins.

• Udeshi et al. utilized the DUB inhibitor PR-619 and the proteasome inhibitor MG-132 to study the effect of DUB and proteasome inhibition on the ubiquitin landscape, at the proteome level, using quantitative high performance mass spectrometry.

• Sims et al. have engineered high-affinity Lys63 polyubiquitin-binding peptides with selectivity for K63- over K48- and K11-linkages. These engineered peptides are the basis for Biotin-K63 TUBE 1, a new tool for the sensitive and selective detection of K63-linked polyubiquitylated proteins.

• TUBEs at work. GST-TUBEs: Enriching ubiquitylated biomarkers and targets for drug discovery at low cost is getting easier. Read the paper.

• A new research article demonstrates the selectivity of Progenra’s novel anti-tumor compound using small molecule inhibitors (PR-619) and DUBs. For more information on DUB activity, check out this paper.

SUMO Expression Systems

LifeSensors’ SUMO technologies are proven to dramatically enhance expression and solubility of heterologous proteins. Our SUMO proteases efficiently remove the SUMO fusion tags, leaving no residues behind, giving you the unaltered protein you designed. The His6-tags make purification fast and simple.

• Cleavable SUMOstar Fusions enable the expression and immunoaffinity purification of recombinant dengue virus 2 NS1. To read more click here.

Ubiquitin Research Tools

LifeSensors offers the largest selection of Ubiquitin Research Tools. Our dedication to the development of innovative regeants and tools allow researchers to investigate the ubiquitin proteasome pathway with ease of mind.

• Deubiquitylases (DUBs) • Substrates • Ubiquitin Conjugation Kits

• DUB Assay Kits • Enzymes • Ubiquitin Affinity Reagents • Antibodies

Custom Biochemical Services

LifeSensors' offers a variety of biochemical services that can be customized to suite your needs.

Our custom services include: Protein Expression and Purification, Custom Substrate and Assay Development, and a variety of Microarray-based Services for Ligase Substrate Identification and for Deubiquitylase Substrate Identification.

Upcoming Meetings

Learn more about LifeSensors.

Representatives will be attending the following meetings:

• ASCB 2012   • PEGS 2012   •  Ubiquitin Drug Disovery &Diagnostics 2012  •
• EB 2012 • SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases  •
• AACR 2012 • SFN 2012 •

LifeSensors Monthly Newsletter.

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Technical Document Library

A complete listing of all documentation on our website for quick access and download. Included are White Papers, Manuals, Plasmid Maps, Application Notes, and Poster Presentations.

	HEADLINES
	Follow us on Twitter @LifeSensorsInc Visit Site >> Human SUMO-3 Patent Expands LifeSensors' Protein Expression Portfolio Malvern, PA, USA — March 7, 2012. LifeSensors, Inc., developer and manufacturer of SUMO-fusion technology used to overcome bottlenecks in protein production, expands its intellectual property and protein expression portfolio with its patent, “Human SUMO-3 For Enhancing Protein Expression” (US 8,119,369 B2), awarded by the United States Patent and Trademark Office last week. Read More >> LifeSensors Announces New Director of Sales and Marketing Expands the Sales and Marketing team at headquarters in Malvern, PA LifeSensors, Inc., a rapidly growing biotech company focused on developing innovative tools to facilitate protein expression and the study of the Ubiquitin Proteasome Pathway (UPP), announced today that they have appointed Dr. Mark Engleka to the position of Sales and Marketing Director. Download PDF >>
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