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LifeSensors

Specialists in ubiquitin and related proteins

LifeSensors is the leading producer of innovative tools that facilitate the study of the Ubiquitin Proteasome Pathway (UPP). We also develop novel technologies that utilize SUMO-fusion tags to improve yield and reduce costs of protein expression.

Ubiquitin Research Tools

Innovative ubiquitin research tools produced to the highest standards

		Ubiquitin Affinity Reagents (TUBES)	Ubiquitin Pathway Antibodies
		Ubiquitin Derivatives and Chains	Ubiquitin ELISA
		Conjugation Assays	Ubiquitin/Ubi Pathway Inhibitors
		Conjugating Enzymes	Ubiquitin Protein Microarray Services
		Isopeptidases - Assays	Custom Ubiquitinated Peptides
		Isopeptidases Enzymes	SilenciX Ubiq. Path. Knockdown Cell Lines
		Isopeptidases - Substrates	Proteasome Research Tools
			SUMO Research Tools

SUMO Expression Systems

SUMO technologies are proven to dramatically enhance expression and solubility of heterologous proteins. Our SUMO proteases efficiently remove the SUMO fusion tags, leaving no residues behind, giving you the unaltered protein you designed. The His6-tags make purification fast and simple. Choose your preferred expression system:
E. coli	Yeast	Insect	Mammalian

Literature Highlights

PR-619 used in study of reversible inactivation of DUBs by reactive oxygen species: Lee et al.
SilenciX stable knockdown cell lines featured in 3 recent papers:Brem and Karran, Sultana R et al. and Abdel-Fatah et al.
TMR (TAMRA)-TUBE2 used to sort ubiquitylated and non-ubiquitylated substrates: M.Spies et al.
Review of technologies, including TUBEs, PR-619 & Ubiquitin Microarray Services, for probing the ubiquitylation and deubiquitylation of cellular proteins
The DUB inhibitor PR-619 and the proteasome inhibitor MG-132 used to study ubiquitin proteome using quantitative high performance mass spectrometry: Udeshi et al.
Engineered high-affinity Lys63 polyubiquitin-binding peptides with selectivity for K63- over K48- and K11-linkages. These engineered peptides are the basis for K63-TUBEs, sensitive and selective reagents for detection of K63-linked polyubiquitylated proteins: Sims et al.
TUBEs at work. GST-TUBEs: Enriching ubiquitylated biomarkers and targets for drug discovery at low cost is getting easier. Read the paper.
Selectivity of PR-619 and P22077 for DUBs: Altun et al.

Technical Document Library

A complete listing of all documentation on our website for quick access and download. Included are White Papers, Manuals, Plasmid Maps, Application Notes, and Poster Presentations.

	HEADLINES
	LifeSensors presented an overview of ubiquitin proteomics at the 3rd GTC Conference, Ubiquitin Research and Drug Discovery, Las Vegas, February 25-26th, 2013. Complexity of ubiquitin pathways leads to frequent questions related to identification of ubiquitin pathway enzymes (E3s and DUBs) and their substrates. An overview of biochemical proteomics for drug discovery applications including Ubiquitin Protein Microarray Services from LifeSensors was presented by Christian Loch, Assistant Director, R&D. Visit our website to find additional information about our Ubiquitin Protein Microarrays. Visit Site >> LifeSensors Inc. appointed 4A Biotech Co.Ltd as another distributor of its innovative reagents and technologies in China Located at Guanglian Industrial Park, Beijing, 4A Biotech Co.Ltd. is a leading life science product provider in China. Visit Site >> LifeSensors presents data at FASEB's Ubiquitin & Cellular Regulation meeting June 24th-29th. Download PDFs of poster #54 "Effect of DUB inhibitor PR-619 on the microtubule network and protein aggregate formation in oligodendroglial cells: Implications for neurodegeneration" and poster #61 "Decoding the information content of ubiquitin chains: Application of linkage-specific TUBES to the ubiquitome" from our Technical Documentation page (bottom of the page). Visit Site >>
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